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2015, Volume 31, Number 2, Page(s) 131-135
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DOI: 10.5146/tjpath.2014.01258 |
Cutaneous Myeloid Sarcoma of the Penile Foreskin |
Ruquiya AFROSE1, Deepa NEBHNANI2, Neelam WADHWA1 |
1Department of Pathology, University College of Medical Sciences, DELHI, INDIA 2Department of Uro-Pathology, Seth G S Medical College and KEM Hospital, MUMBAI, INDIA |
Keywords:
Myeloid leukemia, Chronic phase, Circumcision, Phimosis, Priapism |
Myeloid sarcoma, considered to herald the onset of a blast crisis in the
setting of chronic myeloproliferative neoplasm/dysplasia, typically
presents during the course of the disorder. Cutaneous involvement is
uncommon and lesions on genital skin are seldom seen. We present
a case of a well-differentiated myeloid sarcoma in the penile foreskin
in an apparently healthy 29-year-old male presenting with phimosis.
The unusual composition of the inflammatory cell infiltrate, and
characteristic sparing of dermal blood vessels, nerves and smooth
muscle fibres led to the correct diagnosis. Absence of commonly
observed changes in the circumcision skin like those of balanitis
xerotica was also helpful. Detailed hematological work up revealed a
previously undiagnosed chronic myeloid leukemia in chronic phase.
The patient also had simultaneous priapism, another rare presentation
of chronic myeloid leukemia. One year hence, the patient is in
hematological remission with no evidence of extramedullary disease.
Although priapism has been described as a rare presenting symptom
in chronic myeloid leukemia, the present case is unique as this is the
first time a cutaneous myeloid sarcoma has been documented in the
penile foreskin.
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