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2015, Volume 31, Number 1, Page(s) 030-035     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2014.01279
CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype
Oya Nermin SİVRİKOZ1, Belkız UYAR2, Filiz DAĞ3, Funda TAŞLI1, Salahattin M. SANAL4
1Department of Pathology, Şifa University, Faculty of Medicine, İZMİR, TURKEY
Department of Dermatology, Şifa University, Faculty of Medicine, İZMİR, TURKEY
3Department of Pathology, Tınaztepe Private Hospital, İZMİR, TURKEY
4Department of Oncology, Tınaztepe Private Hospital, İZMİR, TURKEY
Keywords: CXCR-4, COX-2, Basal cell carcinoma, Squamous cell carcinoma, Skin neoplasms

Objective: Both CXCR-4 and COX-2 are biological markers that play a significant role in several neoplastic processes. We explored the differences in expression of these markers in certain subtypes of basal cell carcinoma, and squamous cell carcinomas in general.

Material and Method: In this study, we investigated the differences between 38 patients with basal cell carcinoma (nodular, infiltrative and micro-nodular subtypes) and 24 patients with well-differentiated squamous cell carcinomas with respect to their depth of invasion, tumor location, age, and CXCR-4 and COX-2 expression.

Results: Statistically, we found no significant difference between squamous cell carcinomas and basal cell carcinoma in terms of CXCR-4 and COX-2 expression; however, the degree of marker expression became stronger with increasing depth of invasion in both tumors. The expression of both markers was also higher in infiltrative type basal cell carcinoma compared to all the other subtypes. The results were statistically significant (p<0.05). Additionally, a significantly positive correlation also existed between COX2 and CXCR4 expression (p < 0.05).

Conclusion: The degree of expression of CXCR-4 and COX-2 is related to invasiveness in both malignancies; thus, infiltrative type of basal cell carcinoma displays the highest degree of CXCR-4 and COX-2 expression among all the subtypes. Furthermore, our results indicate that these two biological markers may both be involved in the process of carcinogenesis and require investigation with further molecular and genetic studies in larger series.


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