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2018, Volume 34, Number 1, Page(s) 104-107     
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DOI: 10.5146/tjpath.2014.01297
Dedifferentiated Liposarcoma of the Gastroesophageal Junction
Gökçe AŞKAN1, Pelin BAĞCI1, Meera HAMEED2, Olca BAŞTÜRK2
1Departments of Pathology, Marmara University Faculty of Medicine, İSTANBUL, TURKEY
2Memorial Sloan-Kettering Cancer Center, NEW YORK, USA
Keywords: Gastrointestinal neoplasms, Gastroesophageal junction, Dedifferentiated liposarcoma

Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.

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