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2015, Volume 31, Number 0, Page(s) 004-017
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DOI: 10.5146/tjpath.2015.01311 |
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician |
Karen Gomez-Hernandez1, Shereen Ezzat1, Sylvia L. Asa2, Özgür Mete2 |
1Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
2Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada |
Keywords:
Pituitary adenoma, Acromegaly, Hyperthyroidism, Cushing syndrome |
Pituitary adenomas comprise a heterogenous group of adenohypophyseal tumours with distinct clinicopathological features across both the
clinically functioning and silent groups. Although, predicting a clinically aggressive course remains challenging, accurate subtyping of pituitary
adenomas offers valuable prognostic information that together with other clinical and radiological information serves as a platform for tailored
treatment and follow-up. For instance, silent subtype 3 pituitary adenomas, silent corticotroph adenomas, acidophil stem cell adenomas, Crooke
cell adenomas, and sparsely granulated somatotroph adenomas show more invasive growth. This review has been formulated as a set of practical
questions that address the distinct clinical behaviour of a selected group of pituitary adenoma subtypes.
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