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2015, Volume 31, Number 0, Page(s) 004-017     
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DOI: 10.5146/tjpath.2015.01311
Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician
Karen Gomez-Hernandez1, Shereen Ezzat1, Sylvia L. Asa2, Özgür Mete2
1Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
2Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Keywords: Pituitary adenoma, Acromegaly, Hyperthyroidism, Cushing syndrome

Pituitary adenomas comprise a heterogenous group of adenohypophyseal tumours with distinct clinicopathological features across both the clinically functioning and silent groups. Although, predicting a clinically aggressive course remains challenging, accurate subtyping of pituitary adenomas offers valuable prognostic information that together with other clinical and radiological information serves as a platform for tailored treatment and follow-up. For instance, silent subtype 3 pituitary adenomas, silent corticotroph adenomas, acidophil stem cell adenomas, Crooke cell adenomas, and sparsely granulated somatotroph adenomas show more invasive growth. This review has been formulated as a set of practical questions that address the distinct clinical behaviour of a selected group of pituitary adenoma subtypes.

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