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2015, Volume 31, Number 0, Page(s) 048-059     
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DOI: 10.5146/tjpath.2015.01314
Poorly Differentiated and Undifferentiated Thyroid Carcinomas
Catarina Eloy1,2, Luciana Ferreira1,2, Catarina Salgado1,3, Paula Soares1,2,3, Manuel Sobrinho-Simões1,2,3,4
1Institute of Molecular Pathology and Immunology of the University of Porto, Cancer Biology, Porto, Portugal
2Medical Faculty of Porto University, Pathology and Oncology, Porto, Portugal
3Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
4Hospital Centre of S. João, Pathology, Porto, Portugal
Keywords: Anaplastic thyroid carcinoma, Non-medullary thyroid carcinoma, Molecular medicine, Small cell carcinomas, Poorly differentiated thyroid carcinoma

Thyroid cancer is the most common endocrine malignancy and its incidence goes on increasing worldwide. The majority of thyroid tumours comprise well-differentiated (papillary and follicular) thyroid carcinomas that usually carry an excellent prognosis, while a minority progress to poorly differentiated carcinoma (PDTC) and, ultimately, to the highly aggressive and lethal undifferentiated carcinoma (UTC). Recently, some major advances have been made on the histologic and imunohistochemical identification, as well as on the molecular characterization of PDTC and UTC. In this review we summarize the most recent immunohistochemical and molecular findings in PDTC and UTC, giving a particular emphasis to the diagnostic and prognostic meaning of the genetic alterations.

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