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2017, Volume 33, Number 1, Page(s) 025-029
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DOI: 10.5146/tjpath.2016.01374 |
Expression of Monomeric C-Reactive Protein in Infarcted Brain Tissue from Patients with Alzheimer’s Disease |
Mark SLEVIN1, Donghui LIU1, Glenn FERRIS1, Malik AL-HSINAWI2, Raid AL-BARADIE 2, Jerzy KRUPINSKI3 |
1Manchester Metropolitan University, School of Healthcare Science, Manchester, United Kingdom
2Department of Medical Laboratories, Majmaah University, Al Majma’ah, Saudi Arabia
3Department of Neurology, Hospital Universitari Mutua de Terrassa, Barcelona, Spain |
Keywords:
Monomeric C-reactive protein, Stroke, Alzheimer’s disease, Neurodegeneration, Vascular dementia |
Objective: We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after
stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development
we identified a small group of post-mortem brain samples from individuals who had Alzheimer’s disease and evidence of tissue infarction/
micro-infarction on histological examination.
Material and Method: We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain
tissues.
Results: We showed that monomeric-C-reactive protein deposition was highest in those regions affected by stroke or vascular disruption, and
that within those same areas, there was more interaction and co-localization between major classical proteins of neurodegeneration (β-amyloid
and tau).
Conclusion: We hypothesise that vascular disruption and concomitant release of monomeric-C-reactive protein within the brain tissue could
exacerbate ongoing neurological damage via stimulation of neuro-inflammation and from direct consequences of its action on both neuronal
and vascular cells.
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