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2007, Volume 23, Number 2, Page(s) 098-102     
[ Abstract (Turkish) ] [ Full Text ] [ PDF ] [ Similar Articles ]
Adenomatoid tumor of the female genital tract: Report of three cases
Filiz BOLAT1, N. Emrah KOÇER1, Nebil BAL1, Ümran KÜÇÜKGÖZ2
1Baskent University Faculty of Medicine, Department of Pathology, ANKARA
2Baskent University Faculty of Medicine, Department of Gynecology and Obstetrics, ANKARA
Keywords: Adenomatoid tumor, female genital tract, histogenesis

Adenomatoid tumors are benign proliferations that are most often encountered in the female and male genital tracts. The mesothelial phenotype of these unusual tumors has been established by a variety of ultrastructural and immunohistochemical studies, although their histogenesis is by no means certain. In this paper we report three cases that were diagnosed as genital tract adenomatoid tumors and discussed the clinical signs, origin and immunohistochemical characteristics of the this type of tumor. Immunohistochemical expression of calretinin, HBME-1, vimentin, pancytokeratin, EMA, and CD31 were analyzed in three ATs, using formaline-fixed, paraffin-embedded archival tissues. The age of the patients were ranging from 40 to 46 years with a median of 43.3. Tumors were located in uterus (one), and fallopian tube (two). Tumor sizes were ranging between 0.6-5 cm. Immunohistochemically all tumors exhibited strong and diffuse positivity for pancytokeratin, calretinin, HBME-1 and vimentin, but negativity for EMA, and CD31. The immunohistochemical results support histogenetic theories of the adenomatoid tumor that claim it as a type of benign mesothelioma. Immunohistochemical phenotypes can play an important role in the differential diagnosis.

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