Renal Microsporidiosis in Pediatric Bone Marrow Transplant Recipients: A Case Series

Saloni SHAH; Sheba Sweetline JACOB; Rama MANI; Ashok PARAMESWARAN; Sunil KUMAR; Rajeev A ANNIGERI; Raja MAHESH; Ramya UPPULURI

doi:10.5146/tjpath.2017.01416

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2020, Volume 36, Number 1, Page(s) 068-072

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DOI: 10.5146/tjpath.2017.01416

Renal Microsporidiosis in Pediatric Bone Marrow Transplant Recipients: A Case Series

Saloni SHAH¹, Sheba Sweetline JACOB¹, Rama MANI¹, Ashok PARAMESWARAN¹, Sunil KUMAR¹, Rajeev A ANNIGERI², Raja MAHESH², Ramya UPPULURI³

¹Department of Histopathology, Apollo Hospitals, CHENNAI, TAMIL NADU, INDIA
²Department of Nephrology, Apollo Hospitals, CHENNAI, TAMIL NADU, INDIA
³Department of Hematology, Apollo Hospitals, CHENNAI, TAMIL NADU, INDIA

Keywords: Kidney, Microsporidiosis, Opportunistic infection, Pediatrics, Bone marrow transplantation

Microsporidiosis is a rare, but emerging opportunistic infection in solid organ transplant and stem cell transplant recipients. Renal involvement in microsporidiosis is very rarely seen in these recipients. We describe two cases of pediatric renal microsporidiosis, diagnosed on renal biopsies, following bone marrow transplantation presenting as severe acute kidney injury. The first patient died, whereas the second survived due to early diagnosis based on high index of suspicion and prompt treatment with Albendazole. We believe these are the first such reported cases of renal microsporidiosis in pediatric bone marrow transplant recipients.

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