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2021, Volume 37, Number 3, Page(s) 266-272     
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DOI: 10.5146/tjpath.2021.01523
Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature
Bryan MORALES-VARGAS, Kristin DEEB, Deniz PEKER
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GEORGIA, USA
Keywords: Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma, Splenic tumor, BCOR1L1, JAK2

Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad immunophenotypic profile often causing a diagnostic challenge for pathologists. The molecular features of FDC/FRC sarcoma are largely unknown due to a lack of comprehensive data. Here we present the results of next-generation sequencing and Single Nucleotide Polymorphism Copy Number array analysis in a case of FDC/FRC and review the literature.

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