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2022, Volume 38, Number 1, Page(s) 070-072     
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DOI: 10.5146/tjpath.2021.01534
An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
Poonam Abhay ELHENCE1, Deepak VEDANT1, Saurabh SINGH2, Puneet PAREEK3
1Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, JODHPUR, INDIA
2Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, JODHPUR, INDIA
3Department of Radiation Oncology, All India Institute of Medical Sciences, JODHPUR, INDIA
Keywords: Penis, Granular cell tumour, Benign, Immunohistochemistry

Granular cell tumours are uncommon acquired benign tumours of nerve sheath origin that are usually seen in the head and neck region and upper aero-digestive tract. They usually present as solitary small sized nodules in middle age. The tumour is usually benign and composed of sheets of large sized cells with abundant granular cytoplasm containing lysosomal macro-inclusions known as pustulo-ovoid bodies of Milian (POB) that represent the heterogeneity of the lysosomes. No well-established criteria for malignancy have been described for this tumour. In this article, we have discussed a rare case of granular cell tumour of the penis with its characteristic histomorphology and immunohistochemistry and relevant differential diagnosis.

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