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2022, Volume 38, Number 2, Page(s) 162-166     
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DOI: 10.5146/tjpath.2021.01549
Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
Divakar SHARMA1, Trupti PAI1, Gagan PRAKASH2, Sangeeta DESAI1, Santosh MENON1
1Departments of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, MUMBAI, INDIA
2Departments of Uro-Oncology, Tata Memorial Centre, Homi Bhabha National Institute, MUMBAI, INDIA
Keywords: Low-grade oncocytic tumor, Immunohistochemistry, Oncocytic renal tumors, Emerging renal tumors

Low-grade Oncocytic Tumor (LOT) of kidney is an emerging neoplasm that forms an important differential diagnosis in a spectrum of entities with oncocytic morphology. It has overlapping features with renal oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma, but with distinct clinical, histomorphological and immunohistochemical features. LOT exhibits characteristic low grade oncocytic morphology with a CD117 negative/CK7 positive immunophenotype. Herein, we describe two cases of this emerging entity, LOT, with emphasis on the diagnostic aspects, including the histomorphology, immunoprofile and discussion on the close differentials.

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