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DOI: 10.5146/tjpath.2021.01551 |
Diagnostic Discrepancies Between Intraoperative Frozen Section and Permanent Histopathological Diagnosis of Brain Tumors |
Maher KURDI1, Saleh BAEESA2, Yazid MAGHRABI3, Anas BARDEESI3, Rothaina SAEEDI41, Taghreed AL-SINANI5, Alaa SAMKARI6, Ahmed LARY7, Sahar HAKAMY8 |
1Department of Pathology, King Abdulaziz University, Faculty of Medicine in Rabigh, RABIGH, KINGDOM OF SAUDI ARABIA
2Division of Neurosurgery, King Abdulaziz University, Faculty of Medicine, JEDDAH, KINGDOM OF SAUDI ARABIA3Department of Neuroscience, King Faisal Specialist Hospital and Research Center, JEDDAH, KINGDOM OF SAUDI ARABIA
4Division of Neurosurgery, Department of Surgery, King Abdulaziz University Hospital, JEDDAH, KINGDOM OF SAUDI ARABIA
5King Fahad General Hospital, JEDDAH, KINGDOM OF SAUDI ARABIA
6Department of Pathology and Laboratory Medicine, King Saud Bin Abdulaziz University for Health Science, JEDDAH, KINGDOM OF SAUDI ARABIA
7Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, JEDDAH, KINGDOM OF SAUDI ARABIA
8Center of Excellence in Genomic Medicine Research, King Abdulaziz University, JEDDAH, KINGDOM OF SAUDI ARABIA |
Keywords:
Brain tumor, Histopathology, Frozen section, Diagnostic compatibility |
Objective: Intraoperative frozen section (IOFS) diagnosis of brain tumors plays an important role in assessing the adequacy of the sample and
determining the treatment plan. The aim of this study was to investigate the diagnostic accuracy between IOFS and permanent sections.
Material and Method: The authors reviewed the histopathological results of 383 brain tumors, including IOFS and permanent histological
diagnosis. The cases were classified into three diagnostic compatibilities (i) Perfect fit; the diagnosis of IOFS was identical to the permanent
diagnosis, (ii) Partial compatibility; IOFS diagnosis was not incorrect but was too broad to be considered full compatibility, (iii) Conflict; IOFS
diagnosis is completely different from the permanent diagnosis. The permanent diagnosis was used as a primary criterion and was compared to
IOFS diagnosis and recurrence rate using different statistical methods.
Results: 84% of the patients underwent craniotomy and tumor resection, while 15% only underwent tumor biopsy. Approximately, 53.8 %
of the cases revealed perfect matching in the diagnosis between IOFSs and permanent sections, while 16.2% of the cases revealed complete
mismatching in the diagnosis between the sections. The remaining 30% of the cases showed partial compatibility in the diagnosis between the
two diagnostic methods. There was no significant difference in recurrence rate among all cases of different diagnostic compatibility (p=0.54).
Conclusion: There is a diagnostic discrepancy between IOFSs and permanent sections. However, cases that revealed no consensus in the
diagnoses showed no negative effect on the patient outcome. Further studies should be conducted to explore the reasons of this conflict in the
two diagnostic methods.
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