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2023, Volume 39, Number 2, Page(s) 161-166
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DOI: 10.5146/tjpath.2022.01589 |
Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors |
Nataliia HYRIAVENKO1, Mykola LУNDІN1, Vladyslav SIKORA1, Ruslana CHYZHMA1, Yulia LУNDІNA2, Kateryna SIKORA1, Wireko Andrew AWUAH3, Anatolii ROMANIUK1 |
1Department of Pathology, Sumy State University, SUMY, UKRAINE
2Department of Morphology, Sumy State University, SUMY, UKRAINE
3Department of Student, Sumy State University, SUMY, UKRAINE |
Keywords:
Neuroendocrine tumor, Fallopian tube, Serous adenocarcinoma, Ovary, Multicentric primary tumors |
Neuroendocrine tumors (NETs) comprise a large group of tumors that are most often localized in the gastrointestinal tract and lungs. They are
rarely found in the organs of the female reproductive tract; such NETs are primarily localized in the ovaries. We present a case of multicentric
primary low-grade NET of the fallopian tube and high-grade ovarian serous adenocarcinoma. In both tumor regions, the histotypes of
neoplasms were determined by morphological and immunohistochemical investigations. The NET of the fallopian tube was diffusely positive
for chromogranin A and CD56, but wild type for p53 and negative for CK7, CK20, and ER; Ki-67 expression was observed in 3% of the neoplastic
cells. The ovarian serous adenocarcinoma was positive for CK7 and ER, mutant for p53, but negative for chromogranin A, CK20, and CD56;
Ki-67 expression was observed in 45% of the tumor cells. These results support the possibility that NET can occur in the female reproductive
tract and coexist with other malignant tumors.
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