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2002, Volume 18, Number 1-2, Page(s) 022-024     
[ Abstract (Turkish) ] [ PDF ]
PRIMARY THYMIC CARCINOMA: REPORT OF 2 CASES.
Nil ÇULHACI, Muhan ERKUŞ, Edi LEVİ, Meral UYAR, Serdar ŞEN
Adnan Menderes Üniversitesi Tıp Fakültesi, Patoloji AD., Adnan Menderes Üniversitesi Tıp Fakültesi, Göğüs Cerrahisi AD.

Primary thymic carcinomas are rare neoplasms, and several pathologic variants of such neoplasms have been described. Well-differentiated squamous, low-grade mucoepidermoid, and basaloid carcinoma usually are associated with a favorable prognosis, but other variants are agressive. Our first case is a 57-year old woman with a 6 cm. anterior mediastinal mass. Pathological examination of the tumor revealed epithelial nests with a spindle cell sarcomatous component, and also chondroid areas. A diagnosis of “thymic carcinoma of sarcomatoid type” was made. The second case is a 21-year old woman with a 5,5 cm. anterior mediastinal mass. Pathological examination of the tumor revealed epithelial nests in desmoplastic stroma. Immunohistochemically, the tumor cells showed expression of cytokeratin. Chromogranin also was expressed in a minority of cells, and thus, a diagnosis of “thymic carcinoma with focally neuroendocrine differentiation” was made. Here, we report 2 rare and agressive cases of thymic carcinoma.

[ Abstarct (Turkish) ] [ PDF ]