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2008, Volume 24, Number 2, Page(s) 111-115     
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Inflammatory pseudotumor of the spleen: A case report
Selda SEÇKİN, Kübra YILDIRIM
Ankara Numune Eğitim ve Araştırma Hastanesi, Patoloji Bölümü, ANKARA
Keywords: Inflammatory pseudotumor, spleen

Inflammatory pseudotumors, also known as inflammatory miyofibroblastic tumors, are rare benign tumors of the spleen. The diagnosis of these tumors may be difficult, because they simulate some hematopoetic malignancies, leiomyosarcomas, inflammatory malignant fibrous histiocytoma and inflammatory fibrosclerosing lesions. They frequently occur at lung. But they are reported at gastrointestinal system, orbit, liver, bladder, lymph nodes, heart, brain, mesentery, omentum and spleen. Histologically they are composed of an admixture of cells like lymphocytes, plasma cells, foamy histiocytes, neutrophils and eosinophils with fibrosis, sclerosis and plump fibroblasts. Immunohistochemical stains show diffuse staining of tumor cells with vimentin and less common with myogenic markers like smooth muscle actin, muscle specific actin and desmin. CD 68 and focal cytokeratin immunoreactivity are found. We present a case of 53 year old female. Laboratory investigations were normal. Abdominal ultrasonography showed a heterogenous, hypoechoic nodular mass measuring 30x27 mm in the superior portion of the spleen parenchyma. Splenectomy was performed. Histologically the lesion was composed of inflammatory cells and miyofibroblasts. The case was diagnosed as inflammatory pseudotumor (Inflammatory miyofibroblastic tumor) with histological and immunohistochemical findings.

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