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2008, Volume 24, Number 3, Page(s) 147-152
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CD44 and MMP-2 expression in urothelial carcinoma |
Gülgün ERDOĞAN1, İlknur KÜÇÜKOSMANOĞLU1, Bahar AKKAYA1, Türker KÖKSAL2, Gülten KARPUZOĞLU1 |
1 Akdeniz University, School of Medicine Department of Pathology, ANTALYA
2 Akdeniz University, School of Medicine Department of Urology, ANTALYA |
Keywords:
CD44, MMP-2, urothelial carcinoma |
Aim: CD44, one of the adhesion molecules, is thought to
play an important role in cell-cell and cell-matrix interactions.
Matrix metalloproteinases are degradative
enzymes that remodel extracellular components. In this
study the relation of MMP-2 and CD44 expressions with
the histologic classification and the pathologic stage of
urothelial carcinoma was revealed using immunohistochemistry.
Material and Methods: Thirty-nine patients with urothelial
carcinoma of the bladder were studied. The histological
classification was performed according to
WHO criteria. Patients were grouped as infiltrating
urothelial carcinoma, low grade non-invasive papillary
urothelial carcinoma, and high grade non-invasive papillary
urothelial carcinoma. The pathological staging
was done according to the TNM classification. Immunohistochemical
staining using CD44 and MMP-2 antibodies
was performed on tissue blocks.
Results: CD44 immunoreactivity was detected in 77%
(30/39) of the tumours which was significantly higher in
non-invasive papillary urothelial carcinomas, low grade
non-invasive papillary urothelial carcinomas, high grade
infiltrating urothelial carcinomas (p≥0.05). MMP-2
expression was observed in 69% (27 of 39) of the tumours.
There were no significant differences in MMP-2 expression
between various histologic subtypes and noninvasive
and infiltrative tumours.
Conclusion: In conclusion, higher expression of CD44
is inversely correlated with infiltrative potential of
urothelial carcinoma. These results should be supported
by further studies.
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