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2008, Volume 24, Number 3, Page(s) 174-178
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Three cases of combined small cell lung carcinoma with review of the literature |
İrem Hicran ÖZBUDAK1, Güzide Ayşe GÖKHAN1, Gülay ÖZBİLİM1, Ömer ÖZBUDAK2, Esin ÖZEL3, Alpay SARPER4 |
1 Akdeniz Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, ANTALYA
2 Akdeniz Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, ANTALYA
3 Antalya Patoloji Merkezi, ANTALYA
4 Akdeniz Üniversitesi Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, ANTALYA |
Keywords:
Combined small cell carcinoma, lung |
Combined small cell lung carcinoma is an uncommon
entity and constitutes 1-3% of all cases with small cell
lung carcinoma (SCLC). We reported three cases of
combined small cell lung carcinoma. All the cases were
male (ages: 77, 60 and 55 years, respectively) with a history
of heavy smoking and presented with lung masses.
Additionally, first case had been a history of asbestos
exposure for 5-6 years. Histopathological examination
of biopsy specimens revealed a rare variant of small cell
lung carcinoma ie combined small cell lung carcinoma.
In addition to histological evidence of small cell lung
carcinoma, the first biopsy specimen also contained
areas of squamous cell carcinoma and the other two biopsy
specimens revealed adenocarcinomatous cells. Immunohistochemical
findings supported the diagnosis.
Combined small cell lung carcinoma is very rare, but is
nevertheless a well described diagnostic category among
lung cancers. In this case report, because of the rarity
of these tumors, we discussed combined small cell lung
carcinoma in view of the literature.
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