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2009, Volume 25, Number 1, Page(s) 056-059
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DOI: 10.5146/tjpath.2009.00963 |
Papillary villoglandular carcinoma of cervix with multiple HPV genome |
Haldun UMUDUM1, Almora GÜLERYÜZ2, Ahmet GÖKSEL2, Hakan ÇERMİK1, Abdullah ÇANDAR2 |
1Etimesgut Asker Hastanesi, Patoloji Bölümü, ANKARA, TÜRKİYE
2Etimesgut Asker Hastanesi, Kadın Doğum Kliniği, ANKARA, TÜRKİYE |
Keywords:
Papillary villoglandular adenocarcinoma, multipl HPV genome, chromogenic in situ hybridization, adenocarcinoma in situ |
We report a case of well differentiated villoglandular
adenocarcinoma with adenocarcinoma in situ component.
Patient was an asymptomatic premenopausal
woman, which was referred with atypical glandular
cells of undetermined significance (AGUS) diagnosis
established with cervicovaginal smear. Chromogenic in
situ hybridization showed the presence of dual HPV
(subtype 16/18 and 31/33) genomes. P53 overexpression
and increased Ki 67 expression were detected on both
invasive and in situ component. No evidence of disease
was detected sixty-five months after staging laparotomy.
This case is an uncommon example of multiple
HPV infections leading to unusual cervical tumor.
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