Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2015, Vol 31, Num, 0     (Pages: 155-171)

Syndromes that Link the Endocrine System and Genitourinary Tract

Yasemin Özlük 1, Işın Kılıçaslan 1

1 Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey

DOI: 10.5146/tjpath.2015.01322
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The endocrine system and genitourinary tract unite in various syndromes. Genitourinary malignancies may cause paraneoplastic endocrine syndromes by secreting hormonal substances. These entities include Cushing`s syndrome, hypercalcemia, hyperglycemia, polycythemia, hypertension, and inappropriate ADH or HCG production. The most important syndromic scenarios that links these two systems are hereditary renal cancer syndromes with specific genotype/phenotype correlation. There are also some very rare entities in which endocrine and genitourinary systems are involved such as Carney complex, congenital adrenal hyperplasia and Beckwith-Wiedemann syndrome. We will review all the syndromes regarding manifestations present in endocrine and genitourinary organs.
Keywords : Urogenital system, Endocrine system, SDH, TMEM127, VHL