Summary

In the present study, histopathology of the genital organs and the chromosomes in the bone marrow of the mice that were subjected to the doses of 6µg/day/ mouse of DES for 1, 2 and 3 months periods were examined. A significant increase in the number of chromosomes and structural anomalies have been observed statistically in mice subjected to DES directly (p<0,05). The findings showed histologically, adenosquamous metaplasia in addition to inflammation, endometrial hyperplasia ranged from mild to severe and adhesions in the endometrial cavity in all the groups; severe hyperplasia of goblet cells was found in the group which was exposed to DES for 3 months. In addition, in the groups directly affected by the drug, for 1 and 2 month period the increase in the number of the micronuclei and the anaphasebridge attracted attention.