Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2000, Vol 16, Num, 1-2     (Pages: 017-021)

HEPATIC IRON AND FIBROSIS SCORE AS PREDICTORS OF RESPONSE TO INTERFERON IN CHRONIC HEPATITIS C.

ÇELİKEL Çiğdem Ataizi 1, ÖZDOĞAN Osman 2, EREN Funda 1, AVŞAR Erol 2

1 Marmara Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı
2 Marmara Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı

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Summary

The aim of this study was to assess the following variables as potential predictive factors of complete response to interferon- in chronic hepatitis C patients: age, sex, serum aminotransferase level, necroinflammatory score, fibrosis score, steatosis and hepatic iron distribution. The influence of all these variables about complete response was studied in 40 patients. Each patient was treated for 6 months with interferon-, and then followed up for at least 1 year. According to the improvement status of serum aminotransferase levels during this period, the patients were classified into complete responders, non responders and partial responders. Pretreatment biopsies from all patients were analyzed with no prior knowledge of the efficacy of the treatment. A complete response was predicted only by a low hepatic iron score and by a low fibrosis score. These data indicate that liver biopsy provides useful information for selection of patients with hepatitis C for inreferon- therapy.
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