Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2005, Vol 21, Num, 1-2     (Pages: 011-016)

SCLEROSING HEMANGIOMA OF THE LUNG: CLINICOPATHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES

Yasemin ÖZLÜK 1, Mine G. GÜLLÜOĞLU 1, Alper TOKER 2, Göksel KALAYCI 2, Dilek YILMAZBAYHAN 1

1 İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul
2 İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Göğüs Cerrahisi, İstanbul

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The aim of this study was to demonstrate the immunohistochemical profile of sclerosing hemangioma of the lung (SHL) as well as to analyse its clinicopathological features. Immunohistochemical analysis could be performed in 3 cases for antibodies against TTF-1, surfactant protein-B, NSE, chromogranin A, synaptophysin, CD31, CD34, estrogen and progesteron receptors, cytokeratin 7, EMA, p53 and Ki-67. Positive immunoreactivity for EMA in both cells of SHL supports the epithelial origin of this tumor. Also, immunopositivity for TTF-1 (in both cells), cytokeratin 7 ( in surface cells) and surfactant protein B (in surface cells) leads to pneumocytic differentiation of tumor cells. Positivity for progesterone receptor antibody, although it was detected to be focal, may be associated with the female predominancy of SHL. No evidence of a malignant phenotype was found by Ki-67 and p53, similar with literature. The results of our study were discussed and compared with literature.

Keywords : Lung, sclerosing hemangioma, immunohistochemistry