Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2009, Vol 25, Num, 3     (Pages: 118-121)

Micronodular Thymoma with Lymphoid Stroma: Case Report

Ebru ÇAKIR 1, Funda DEMİRAĞ 1, Göktürk FINDIK 2, Sadi KAYA 2

1 Departments of 1

DOI: 10.5146/tjpath.2009.01165
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A 77-year-old female with a history of hypertension was admitted to our hospital for cough lasting for 1 year. Computed tomography showed a 5x4x3 cm nodular anterior mediastinal mass. A complete surgical resection of the tumor was performed by median sternotomy. Macroscopically the mass 5x4x3 cm was surrounded by a thin capsule. Microscopically a tumoral tissue characterized by a proliferation of multiple epithelial nodules seperated by an abundt lymphoid tissue was seen. The surrounding lymphoid tissue contained a dense proliferation of small lymphocytes forming lymphoid follicles with prominent germinal centers. Immunohistochemically, the epithelial cells were positive for pancytokeratin and CK5/6, lymphoid follicles were positive for CD20 and few scattered lymphoid cells in and around the nodules were positive for CD 3 and CD5. Histopathologic diagnosis was micronodular thymoma.

It is important to differentiate these tumors from other types of thymomas because of their association with low grade lymphomas. A rare case of micronodular thymoma was presented and discussed with the literature.

Keywords : Micronodular thymoma, Histology, Immunohistochemistry