Fibroosseous lesions of the cranial and facial bones are usually benign and tend to grow slowly, yet act aggressively clinically. If not totally excised, recurrence is common in these locally destructive and deforming lesions. Degeneration into sarcoma has been reported in recurred lesions, as well. Diagnosis, classification and treatment of these lesions have exposed various difficulties in the past. Predilection sites are maxillae and mandibles. They are often seen in children and young adults.

In this study 43 cases from Ege University Medical School Surgical Pathology Department between 1976 and 2004, and 12 cases from Uludag University Medical School Surgical Pathology Department between 2003 and 2006 were reviewed. Cases were noted as for age, gender, lesion site, lesion type, histological properties, recurrence, and degeneration into sarcoma.

In conclusion we suggest that specific diagnosis of fibroosseous lesions of cranial and facial bony regions should rely on clinicopathological correlation and radiological findings along with pathological criteria.