Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2012, Vol 28, Num, 1     (Pages: 024-030)

Childhood Fibroblastic and Myofibroblastic Tumors: A Multicenter Documentation and Review of the Literature

Ayper KAÇAR 1, İrem PAKER 2, Diclehan ORHAN 3, Aylar POYRAZ 4, Aylin OKÇU HEPER 5, Nilüfer ARDA 6, Esin BODUROĞLU 6

1 Department of Pathology, Ankara Children's Hematology and Oncology Research and Training Hospital, ANKARA, TURKEY
2 Department of 2nd Pathology, Dışkapı Yıldırım Beyazıt Research and Training Hospital, ANKARA, TURKEY
3 Department of Child Health and Diseases, Pediatric Pathology Unit, Hacettepe University, Faculty of Medicine, ANKARA, TURKEY
4 Department of Pathology, Gazi University, Faculty of Medicine, ANKARA, TURKEY
5 Ankara University, Faculty of Medicine, ANKARA, TURKEY
6 Dr. Sami Ulus Child Diseases Research and Training Hospital, ANKARA, TURKEY

DOI: 10.5146/tjpath.2012.01093
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Objective: In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/myofibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject.

Material and Method: A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and myofibroblastic group according to World Health Organization criteria were collected.

Results: The study comprised 407 soft tissue tumors in total. Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases) of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory myofibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. The only malignant case was an infantile fibrosarcoma.

Conclusion: Infantile fibrosarcoma was lower than reported series and a male predominance was noted. The low incidence of newly described entities as well suggests that these tumors may have been unrecognized.

Keywords : Neoplasms, Fibrous tissue, Pediatric, Infant