Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2012, Vol 28, Num, 2     (Pages: 110-118)

The Relationship Between the Stromal Mast Cell Number, Microvessel Density, C-erbB-2 Staining and Survival and Prognostic Factors in Colorectal Carcinoma

Bahar ELEZOĞLU 1, Şahsine TOLUNAY 2

1 Department of Pathology, M.H. Ağrı State Hospital, AĞRI, TURKEY
2 Department of Pathology, Uludağ University, Faculty of Medicine, BURSA, TURKEY

DOI: 10.5146/tjpath.2012.01109
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Objective: Colorectal adenocarcinomas take second place among the causes of death from carcinoma, and account for 98% of colorectal carcinomas. There is a need to determine new prognostic factors because of high frequency and significance.

Material and Method: 204 colorectal carcinomas diagnosed between 01.01.2005 - 31.12.2008 at Uludağ University Medical Faculty Pathology Department were studied for Factor VIII and c-erbB-2 immunohistochemically and with toluidine blue stain histochemically. Association of mast cell number, microvessel density, and c-erbB-2 staining pattern with survival and known prognostic factors was evaluated.

Results: Follow-up period was 4-60 months. A total of 111 cases were alive, and 65 had died. The mean number of mast cells was 8.00 (1-21) and the mean density of microvessels was 10.00 (2-21). Five-year survival rate of the mast cell group was 48.3% for values under 10 and 57.9% for values of 10 and higher. Five-year survival rate was 58.2% in the group with a microvessel density of 10 and above and 45.9% for values under 10. Five-year survival rate was 53.9% for the group with c-erbB-2 cytoplasmic staining and 48.2% for the group with membranous staining.

Conclusion: The grade increased with the number of mast cells, while survival decreased with an increase in the number of mast cells. The ratio of c-erbB-2 staining increased as the grade and stage increased. There was an association between mast cell number and microvessel density. We found no relationship between prognosis and c-erbB-2, mast cell number, and microvessel density.

Keywords : Prognosis, Colorectal carcinoma, Mast cells, Human, erbB2 protein