Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2014, Vol 30, Num, 2     (Pages: 137-141)

Osteosarcoma Arising from a Haemangioma: Case Report and Review of the Literature

Paul MALLİNSON 1, Tyler COUPAL 2, Malcolm HAYES 3, Paul CLARKSON 4, Peter MUNK 1, Hugue OUELLETTE 1

1 Department of Radiology, Vancouver General Hospital/University of British Columbia, VANCOUVER/BC, CANADA
2 McMaster University, De Groote Medical School, HAMILTON/ONTARIO, CANADA
3 Departments of Pathology, BC Cancer Agency, VANCOUVER BC, CANADA
4 Departments of Surgery, BC Cancer Agency, VANCOUVER BC, CANADA

DOI: 10.5146/tjpath.2013.01206
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To create awareness of the benign lesions from which osteosarcoma may arise.

Osteosarcoma is a rare tumour of bone the etiology of which is poorly understood, but it may arise from benign lesions. Malignant transformation in hemangiomas, in the absence of prior radiation, is exceedingly rare and the resulting neoplasm is usually an angiosarcoma. We report the case of a 30-year-old woman where investigation for thigh pain revealed a distal femoral hemangioma. She represented with pain and mass 18 years later, leading to a confirmed diagnosis of osteosarcoma at the same site.

Osteosarcomas may arise from a variety of benign lesions. In this article we report the case of a histologically confirmed hemangioma which subsequently underwent malignant change into an osteosarcoma.

Keywords : Osteosarcoma, Neoplastic cell transformation, Hemangioma