Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2014, Vol 30, Num, 2     (Pages: 094-099)

Caveolin-1 Expression in Odontogenic Cysts and Ameloblastomas

Zohreh JAAFARI-ASHKAVANDI 1, Soheil PARDIS 1, Maryam ASADZADEH 1, Azadeh ANDISHEH-TADBIR 1, Ali DEHGHANI-NAZHVANI 1

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, SHIRAZ, IRAN

DOI: 10.5146/tjpath.2014.01241
Viewed: 3457
 - 
Downloaded : 2656

Objective: The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors.

Material and Method: In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic).

Results: Positive immunohistochemical reaction was found in 100% of odontogenic cysts and this was significantly more than both unicystic (65%) and solid (55%) ameloblastomas.

Conclusion: The present study showed the expression of caveolin-1 in all odontogenic cysts and more than ameloblastomas. The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.

Keywords : Ameloblastoma, Odontogenic cyst, Caveolin-1, Immunohistochemistry