Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2018, Vol 34, Num, 1     (Pages: 104-107)

Dedifferentiated Liposarcoma of the Gastroesophageal Junction

Gökçe AŞKAN 1, Pelin BAĞCI 1, Meera HAMEED 2, Olca BAŞTÜRK 2

1 Departments of Pathology, Marmara University Faculty of Medicine, İSTANBUL, TURKEY
2 Memorial Sloan-Kettering Cancer Center, NEW YORK, USA

DOI: 10.5146/tjpath.2014.01297
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Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.

Keywords : Gastrointestinal neoplasms, Gastroesophageal junction, Dedifferentiated liposarcoma