Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2020, Vol 36, Num, 3     (Pages: 188-194)

The Contribution of Additional Sampling in Cholecystectomy Materials: A Multicenter Prospective Study

Samir ABDULLAZADE 1, Fahire Göknur AKARCA 2, Güldal ESENDAĞLI 2, Nesrin TURHAN 3, Esra ERDEN 4, Berna SAVAŞ 4, Fatma MARKOÇ 5, Deniz TUNÇEL 6, Banu Özgüven YILMAZ 6, Burcu SAKA 7, Sevinç Hallaç KESER 8, Selma Şengiz ERHAN 9, Zühal GÜCİN 10, Özgül SAĞOL 11, Anıl Aysal AĞALAR 11, Sevinç ÇELİK 12 , Hatice ÖZER 13 , İpek ERBARUT SEVEN 14 , Çiğdem Ataizi ÇELİKEL 14, Özgür EKİNCİ 2, Hatice Reyhan EĞİLMEZ 13, Serdar BALCI 15, Gülen AKYOL 2

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2 Department of Medical Pathology, Gazi University, Faculty of Medicine, ANKARA, TURKEY
3 Department of Pathology, Turkey Yüksek İhtisas Education and Research Hospital, ANKARA, TURKEY
4 Department of Medical Pathology, Ankara University, Faculty of Medicine, ANKARA, TURKEY
5 Department of Pathology, Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, ANKARA, TURKEY
6 Şişli Etfal Education and Research Hospital, İSTANBUL, TURKEY
7 Department of Medical Pathology, Medipol University, Faculty of Medicine, İSTANBUL, TURKEY
8 Department of Pathology, Lütfi Kırdar Education and Research Hospital, İSTANBUL, TURKEY
9 Okmeydanı Education and Research Hospital, İSTANBUL, TURKEY
11 Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY
12 Bozok University, Faculty of Medicine, YOZGAT, TURKEY
13 Cumhuriyet University, Faculty of Medicine, SİVAS, TURKEY
14 Marmara University, Faculty of Medicine, İSTANBUL, TURKEY
15 Pathologist, ANKARA, TURKEY

DOI: 10.5146/tjpath.2020.01483
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Objective: Cholecystectomy materials are frequently encountered in routine practice. The aim of this study was to determine the true frequency of gallbladder lesions, the diagnostic consistency, and standardization of reports after macroscopic sampling and microscopic evaluation based on previously defined criteria.

Material and Method:14 institutions participated in the study within the Hepato-Pancreato-Biliary Pathology Study Group. Routinely examined cholecystectomies within the last year were included in the study in these institutions. Additional sampling was performed according to the indications and criteria. The number of blocks and samples taken in the first macroscopic examination and the number of blocks and samples taken in the additional sampling were determined and the rate of diagnostic contribution of the additional examination was determined.

Results: A total of 5,244 cholecystectomy materials from 14 institutions were included in the study. Additional sampling was found to be necessary in 576 cases (10.98%) from all institutions. In the first macroscopic sampling, the mean of the numbers of samples was approximately 4 and the number of blocks was 2. The mean of the numbers of additional samples and blocks was approximately 8 and 4, respectively. The diagnosis was changed in 144 of the 576 new sampled cases while the remaining 432 stayed unaltered.

Conclusion: In this study, it was observed that new sampling after the first microscopic examination of cholecystectomy materials contributed to the diagnosis. It was also shown that the necessity of having standard criteria for macroscopic and microscopic examination plays an important role in making the correct diagnosis.

Keywords : Gallbladder, Cholecystectomy, Dysplasia, Cancer, Macroscopy