Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2023, Vol 39, Num, 2     (Pages: 161-166)

Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors

Nataliia HYRIAVENKO 1, Mykola L& 1, Vladyslav SIKORA 1, Ruslana CHYZHMA 1, Yulia L& 2, Kateryna SIKORA 1, Wireko Andrew AWUAH 3, Anatolii ROMANIUK 1

1 Department of Pathology, Sumy State University, SUMY, UKRAINE
2 Department of Morphology, Sumy State University, SUMY, UKRAINE
3 Department of Student, Sumy State University, SUMY, UKRAINE

DOI: 10.5146/tjpath.2022.01589
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Neuroendocrine tumors (NETs) comprise a large group of tumors that are most often localized in the gastrointestinal tract and lungs. They are rarely found in the organs of the female reproductive tract; such NETs are primarily localized in the ovaries. We present a case of multicentric primary low-grade NET of the fallopian tube and high-grade ovarian serous adenocarcinoma. In both tumor regions, the histotypes of neoplasms were determined by morphological and immunohistochemical investigations. The NET of the fallopian tube was diffusely positive for chromogranin A and CD56, but wild type for p53 and negative for CK7, CK20, and ER; Ki-67 expression was observed in 3% of the neoplastic cells. The ovarian serous adenocarcinoma was positive for CK7 and ER, mutant for p53, but negative for chromogranin A, CK20, and CD56; Ki-67 expression was observed in 45% of the tumor cells. These results support the possibility that NET can occur in the female reproductive tract and coexist with other malignant tumors.

Keywords : Neuroendocrine tumor, Fallopian tube, Serous adenocarcinoma, Ovary, Multicentric primary tumors