Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2024, Vol 40, Num, 1     (Pages: 001-009)

Cardiac Amyloidosis: Clinical Features, Pathogenesis, Diagnosis, and Treatment

Asuman ARGON 1, Deniz NART 2, Funda YILMAZ BARBET 2

1 Department of Pathology, Health Sciences University, Izmir Faculty of Medicine, IZMIR, TURKEY
2 Ege University, Faculty of Medicine, IZMIR, TURKEY

DOI: 10.5146/tjpath.2023.12923
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Cardiac amyloidosis is a type of amyloidosis that deserves special attention as organ involvement significantly worsens the prognosis. Cardiac amyloidosis can be grouped under three main headings: immunoglobulin light chain (AL) amyloidosis that is dependent on amyloidogenic monoclonal light chain production; hereditary Transthyretin (TTR) amyloidosis that results from accumulation of mutated TTR; and wild-type (non-hereditary) TTR amyloidosis formerly known as senile amyloidosis. Although all three types cause morbidity and mortality due to severe heart failure when untreated, they contain differences in their pathogenesis, clinical findings, and treatment. In this article, the clinical features, pathogenesis, diagnosis, and treatment methods of cardiac amyloidosis will be explained with an overview, and an awareness will be raised in the diagnosis of this disease.

Keywords : Amyloid, Cardiac amyloidosis, Transthyretin, Hereditary amyloidosis, Senile amyloidosis