Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2009, Vol 25, Num, 1     (Pages: 056-059)

Papillary villoglandular carcinoma of cervix with multiple HPV genome

Haldun UMUDUM 1, Almora GÜLERYÜZ 2, Ahmet GÖKSEL 2, Hakan ÇERMİK 1, Abdullah ÇANDAR 2

1 Etimesgut Asker Hastanesi, Patoloji Bölümü, ANKARA, TÜRKİYE
2 Etimesgut Asker Hastanesi, Kadın Doğum Kliniği, ANKARA, TÜRKİYE

DOI: 10.5146/tjpath.2009.00963
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We report a case of well differentiated villoglandular adenocarcinoma with adenocarcinoma in situ component. Patient was an asymptomatic premenopausal woman, which was referred with atypical glandular cells of undetermined significance (AGUS) diagnosis established with cervicovaginal smear. Chromogenic in situ hybridization showed the presence of dual HPV (subtype 16/18 and 31/33) genomes. P53 overexpression and increased Ki 67 expression were detected on both invasive and in situ component. No evidence of disease was detected sixty-five months after staging laparotomy. This case is an uncommon example of multiple HPV infections leading to unusual cervical tumor.

Keywords : Papillary villoglandular adenocarcinoma, multipl HPV genome, chromogenic in situ hybridization, adenocarcinoma in situ