Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Ankara Patoloji Bülteni Archive

2001, Vol 18, Num, 3     (Pages: 018-021)

The detection of HPV by insitu hybridization in cervical neoplasia

Ali Ahmed Muhamad1, Handan Kaya1, Gülsün Ekicioğlu2, Sevgi Küllü1

1Marmara Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, İSTANBUL
2Marmara Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Patoloji Laboratuvar Bölümü, İSTANBUL


Human papillomavirus (HPV) is known to be an important etiopathogenetic factor in intraepithelial neoplasia and invasive squamous cell carcinomas of the cervix. We detected HPV DNA occurrence and subtypes in 18 intraepithelial neoplasia and 14 squamous cell carcinomas of the cervix by in situ hybridisation technique. We revealed a statistically significant difference for the HPV DNA occurrence between intraepitelial neoplasias and carcinomas (p<0.05). While we could not demonstrate any statistically significant correlation between intraepitelial neoplasias and carcinomas for the HPV subtype 6/11, we found a statistically significant correlation between intraepitelial neoplasia and carcinomas with HPV subtype 16/18 (p<0.04).

Keywords : HPV DNA, in situ hibridizasyon, serviks, neoplazm, HPV DNA , in situ hybridization, intraepithelial, cervix, neoplasia