Histologically, tumor cells were uniform, with abundant clear cytoplasm sharply outlined cell membranes, a large centrally located nucleus, with one or two prominent nucleoli.
The tumor cells were typically arranged in nests outlined by fibrous bands; these bands were infiltrated by lymphocytes, plasma cells and multinucleated giant cells (Figures 1, 2).
Figure 1: Germ cell tumor, (H&E; x40).
Immunohistochemically the tumor cells exhibited reactivity for placental alkaline phosphatase (PLAP) (Figure 3) and CD117 ( Figure 4), and were negative for cytokeratin AE1-AE3, alpha1-fetoprotein and human chorionic gonadotropin (hCG).
Immunohistochemically the tumor cells exhibit intermediate to high cytoplasmic reactivity for PLAP, CD117[10,11]. They are negative for cytokeratin AE1-AE3, alpha1-fetoprotein and hCG.
Extragonadal localization is a rarity, and to exclude primary germ cell tumor of male and female gonads is a necessity. This case is valuable due to its rarity.
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