Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2001, Vol 17, Num, 1-2     (Pages: 007-010)

HISTOPATHOLOGIC CLASSIFICATION OF NEUROBLASTOMAS BY MODIFIED SHIMADA SYSTEM (A RETROSPECTIVE STUDY WITH 35 CASES):

AKTAŞ Safiye 1, ORTAÇ Ragıp 1, DİNİZ Gülden 1, ERBAY Ayşe 2, KARACA İrfan 3, KIZILAY Nazihat 4, VERGİN Canan 5

1 Behçet Uz Çocuk Hastanesi Onkoloji Grubu, Patoloji Bölümü İzmir
2 Behçet Uz Çocuk Hastanesi Onkoloji Grubu, Pediatrik Onkoloji Bölümü İzmir
3 Behçet Uz Çocuk Hastanesi Onkoloji Grubu, Çocuk Cerrahisi Bölümü İzmir
4 Behçet Uz Çocuk Hastanesi Onkoloji Grubu, Radyoloji Bölümü İzmir
5 Behçet Uz Çocuk Hastanesi Onkoloji Grubu, Pediatrik Hematoloji Bölümü İzmir

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Summary

Neuroblastic tumors are a heterogen group of tumors occuring in different organs having varying mixed macroscopic and microscopic features. Children’s Cancer Group and Paediatric Oncology Group had represented a risk categorisation system for neuroblastomas (NB). In this system, low, intermediate and high risk groups are classified and treated depending on age, myc-N amplification, favourable/unfavourable histology and DNA ploidy. International Neuroblastoma Committee had improved modified Shimada classification to determine favourable/unfavourable histology groups. In this study the histopathology of 35 NB cases were reviewed and classified according to the modified Shimada classification system depending on age, degree of differentiation and mitotic/caryorrhectic index. Thirty (85.7%) cases were in unfavourable histology group, while 5 cases (14.3%) were in favourable histology group. Stage was found in negative relationship with survival and prognosis, favourable/ unfavourable histology classification was related with prognosis, stage and response to therapy. Differentiation status was in negative relationship with survival.
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