Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2006, Vol 22, Num, 2     (Pages: 087-091)

The use of Ber-EP4 antigen in the differential diagnosis of basosquamous carcinoma from squamous and basal cell carcinoma

Nermin KARAHAN 1, Şirin BAŞPINAR 2, Mehmet YILDIRIM 3, İbrahim BARUT 4

1 Department of Pathology, Suleyman Demirel University School of Medicine, ISPARTA
2 Department of Pathology, Egirdir Bone Joint Diseases Treatment and Rehabilitation Hospital, ISPARTA
3 Department of Dermatology, Suleyman Demirel University School of Medicine, ISPARTA
4 Department of Surgery, Suleyman Demirel University School of Medicine, ISPARTA

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Basal cell and squamous cell carcinoma of skin are common tumors which can be easily distinguished on hematoxylin and eosin stained sections, but basosquamous carcinoma is a controversial entity. The aim of our study was to distinguish basal cell carcinoma and basosquamous carcinoma using Ber-EP4, immunohistochemically in 52 skin tumors. Twenty basal cell carcinomas, 20 squamous cell carcinomas, 10 basosquamous carcinomas and 2 collision tumors of the skin were stained with Ber-EP4 immunohistochemically. All basal cell carcinomas were stained strongly and diffusely with Ber-EP4, whereas squamous cell carcinomas were not, and basosquamous carcinomas were partially stained. Our results suggest that, distinction of basal cell carcinoma and basosquamous carcinoma can be achieved with routine immunohistochemical Ber-EP4 staining.

Keywords : Ber-EP4, basal cell carcinoma, basosquamous carcinoma, squamous cell carcinoma