CD44, a cell adhesion molecule, has been proposed to be important in promoting tumor progression and dissemination. There are many studies about expression of CD44 in many tumors such as gastrointestinal tract, lung, cervix, and liver. Different data have been found about CD44 expression. Ki67 is an indicator that is used to predict the proliferative capacity as well as the prognosis of tumors. The aim of this study was to investigate the expression of CD44 and Ki67 in gastric carcinoma and their relationship between clinicopathologic parameters such as grade, depth of invasion, lymph node metastases and vascular invasion. Immunohistochemical study for CD44 was carried out in 48 formaldehyde fixed, paraffin embedded sections of gastric carcinoma. The results showed that, CD44 and Ki67 did not correlate with the clinicopathologic parameters except grade. High levels of CD44 and Ki67 expressions observed with higher grades. It is concluded that CD44 and Ki67 may be related with the differentiation of gastric carcinoma however they are not correlated with the tumor progression and dissemination. However further studies are required to understand the role of CD44 in metastases and progression of gastric carcinoma.