Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2009, Vol 25, Num, 2     (Pages: 013-019)

Cox-2 Expression and Microvessel Density in Clear Cell Type Renal Cell Carcinoma

Hasan GÜÇER 1, Elife ŞAHAN 2, Ayşenur AKYILDIZ İĞDEM 2, Ü. Seza TETİKKURT 2, Nusret ERDOĞAN 2

1 S.B. Kars Devlet Hastanesi, Patoloji Bölümü, KARS, TÜRKİYE
2 Taksim Eğitim ve Araştırma Hastanesi, Patoloji Bölümü, İSTANBUL, TÜRKİYE

DOI: 10.5146/tjpath.2009.00966
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Objective: Overexpression of cyclooxygenase-2 (COX-2) and its association with angiogenesis have been shown in various carcinomas. In this study, we investigated COX-2 expression in clear cell type renal cell carcinoma and its association with microvessel density and various clinicopathologic parameters.

Material and Method: Fifty cases of clear cell type renal cell carcinoma that underwent radical nephrectomy were included in this study. Th e status of COX-2 expression was examined immunohistochemically. Microvessel density in the neoplasm was estimated using the computerized image-analizer system. We evaluated the correlation between COX-2 expression, microvessel density and clinicopathologic findings.

Results: COX-2 expression was observed in 76% of the cases. Th ere was no association between COX-2 expression and microvessel density, age, sex, tumor size, nuclear grade and stage (p>0.05).

Conclusion: Most clear cell type renal cell carcinomas expressed COX-2, but there was no relationship between COX-2 and various clinicopathologic parameters. Similar studies to explore therapeutic agents that target these specialities can be useful in the treatment of renal cell carcinomas which show COX-2 expression and high vascularity.

Keywords : Renal cell carcinoma, COX-2, Immunohistochemistry, Microvessel density